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Enfermedades infecciosas, Pediatría
Doctora en Medicina Betsy C. Herold
Virus del herpes simple
Vacunas y antivirales
COVID-19
- Chief de la División de Enfermedades Infecciosas Pediátricas
- Cátedra Harold y Muriel Block en Pediatría
- Chair de Investigación
- Director, Centro de Investigación de Prevención Traslacional, Children’s Hospital at Montefiore
- Profesor de Pediatría, Facultad de Medicina Albert Einstein
- Profesor del Departamento de Pediatría (Enfermedades Infecciosas Pediátricas)
- Profesor, Departamento de Microbiología e Inmunología
- Profesor, Departamento de Obstetricia y Ginecología y salud de las mujeres
- Cátedra Harold y Muriel Block en Pediatría
- Chair de Investigación, Departamento de Pediatría
- Chief, División de Enfermedades Infecciosas Pediátricas, Departamento de Pediatría
- Director del Centro de Investigación Traslacional para la Prevención
Areas of Expertise
Resumen del experto
Dr. Herold directs a translational research program focused on the interactions between viruses and their host and using that knowledge to develop novel treatment and prevention strategies. Through her basic science studies, Dr. Herold has developed a unique candidate vaccine to prevent herpes simplex virus (HSV) infections, which is being advanced for phase I clinical trials. Studies of this vaccine uncovered a previously unappreciated immune evasion strategy; this knowledge may accelerate the development of drugs to bolster vaccine and monoclonal antibody efficacy against a range of pathogens.
Her studies on HIV focus on the development of safe and effective pre-exposure prophylactic strategies and on investigating how HSV interacts with HIV to reactivate HIV. Dr. Herold's team also has discovered a previously unrecognized phenomenon in cell biology in which HSV and other viruses activate a mechanism that helps them gain entry and infect healthy cells. This provides a novel target for the development of new antiviral drugs.
Most recently, her lab has studied why children respond differently and are relatively protected from severe COVID-19. Defining the differences in the immune response in children compared to adults will provide insights into protective immunity against this virus and future pandemic viruses.
Her clinical research focuses on infections in pediatric transplant recipients. Dr. Herold helped established and is co-chair of the Pediatric Infectious Diseases Society Transplant Research Network (PIDTRAN), which supports and promotes projects to prevent and treat infectious diseases among child transplant recipients. Dr. Herold has served on the Office of AIDS Research Advisory Council and on the Pediatric Infectious Diseases Society Council. She has been continuously funded by the NIH since 1989. Dr. Herold has over 180 publications in peer-reviewed journals and has presented her work internationally.
