Summary

We believe extreme longevity is due to specific genes which function to delay aging and prevent disease. The purpose of the research is to identify the genes/mutations associated with healthier aging; to understand the biological functions of these genes/mutations; and to develop therapies to replicate these preservative genetic activities in individuals who do not have the genetic profile for longevity.

Age: 65 Years and older

Gender: All

Start Date: 07/01/1998

Primary Completion Date (Estimated): 12/01/2032

Study Completion Date (Estimated): 12/01/2032

Accepts Healthy Volunteers: No

Trial Purpose and Description

Eligibility Criteria

Age: 65 Years and older

Gender: All

Accepts Healthy Volunteers: No

Inclusion criteria:

* Ashkenazi Jewish, age 95+,

* Offspring of person age 95+,

* Offspring of parents who died age 70 or younger.

Exclusion criteria:

* Non-Ashkenazis