About Palmoplantar Keratoderma I, Striate, Focal, or Diffuse
The New York Center for Rare Diseases supports the mission and guidelines of the Genetic and Rare Diseases Information Center (GARD). The following information is provided by the NIH.
Summary
Palmoplantar keratoderma I, striate, focal or diffuse is a skin disease that causes thickening of the skin on the palms of the hands and soles of the feet. The striate form of this disease is characterized by thick, scaly lines on the fingers and palms, with the thickening occurring most often in areas that experience a lot of pressure and rubbing. People with focal and diffuse forms have also been described. The condition is caused by changes in the DSG1 gene.
Causes
What Causes This Disease?
Genetic Mutations: Palmoplantar keratoderma I, striate, focal, or diffuse is caused by genetic mutations, also known as pathogenic variants. Genetic mutations can be hereditary, when parents pass them down to their children, or they may occur randomly when cells are dividing. Genetic mutations may also result from contracted viruses, environmental factors, such as UV radiation from sunlight exposure, or a combination of any of these.
If you suspect you may have this disease, you may want to start collecting your family health history. Information such as other family members who have had similar symptoms, when their/your symptoms first appeared, or exposures to any potential disease-causing environmental factors should be discussed with your medical team.