Department of Emergency Medicine Division of Research and Clinical Investigation

Man in a pink shirt explains cardiac rhythm data displayed on a large screen during a medical presentation.

Science at the Heart of Emergency Medicine

The Department of Emergency Medicine at Montefiore Einstein is home to a dynamic and impactful clinical research program dedicated to advancing health outcomes and alleviating suffering for the patients and communities we serve. Over the past 25 years, our faculty have led numerous clinical trials that have helped shape emergency care practices globally.

Our research efforts are led by Dr. Benjamin Friedman, Professor of Emergency Medicine and Vice Chair for Clinical Investigation (Research). A nationally recognized expert in comparative effectiveness research for acute pain management and a recipient of the Lifetime Achievement Award from the New York American College of Emergency Physicians (ACEP), Dr. Friedman has guided our Department’s longstanding commitment to high-quality, patient-centered investigation.

We have also contributed significantly to public health efforts, including initiatives focused on substance use and sexually transmitted infection (STI) prevention. Since 2020, with the addition of Dr. Carlo Lutz, Director of Clinical and Research Innovation, our research portfolio has expanded to include digital health, biodesign and implementation science. These new directions explore how technology can be equitably and effectively deployed to improve access, efficiency and care delivery in emergency medicine.

The Emergency Medicine Research Division welcomes collaboration across departments and institutions. If you are interested in partnering on research initiatives, please contact our team at EM_research@montefiore.org.

Montefiore physician in a white coat points to a digital asthma education module while speaking with a patient.

Current Projects & Areas of Interest

Our active research projects are focused on improving acute pain management, critical care delivery, and care transitions after your ED visits. Currently approved Institutional Review Board (IRB) protocols include the following:

Antiemetic Fosaprepitant to Remedy Nausea and Vomiting: A Randomized Controlled Trial

PI: M. Manzur

Prevalence of Viral Infections among ED Asthma Patients: A Prospective Cohort Study

PI: C. Lutz

Bridging the Gap: Assessing Digital Health Literacy and Readiness for Behavioral Change in Emergency Department Populations

PI: C. Lutz

Validation of Remote Stethoscope and AI-Powered Wheeze Detection Algorithm

Sponsor: AEVICE MD
PI: C. Lutz

Hospital Airway Resuscitation Trial (HART)

Site Director: C. Lutz

Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (ICECAP)

Site Director: B. Friedman

A Prospective Cohort Study to Determine the Test Characteristics of the Aortic Dissection Detection Risk Score and D-dimer for Aortic Dissection

PI: B. Friedman

Ibuprofen With Or Without Dexamethasone for Acute Radicular Low Back Pain. A randomized trial

PI: E. Irizarry

Duloxetine for Patients With Low Back Pain Who Fail to Improve with Oral NSAIDs. A Randomized Placebo-Controlled Exploratory Study

PI: B. Friedman

Recently Completed Research Projects

Larsen, E., Song, X., Joachim, D., Ch’en, P., Green, S., Hunt, E., Kaur, S., Nag, R., Pisani, O., Thomas, S., Adewunmi, V., Lutz, C., Baghizadeh-Toosi, B., Feldman, J., and Jariwala, S.

This three-month prospective cohort study evaluated the efficacy of a respiratory-responsive vocal biomarker (RRVB) accessible via smartphone application as a real-time monitoring tool for asthma exacerbations. The study enrolled 84 asthma patients who provided daily six-second vocal samples to generate RRVB scores, assessing the biomarker’s ability to predict asthma exacerbations and respiratory states defined by peak expiratory flow and self-reported well-being using risk ratios and confidence intervals.

Gutnick, D., Lutz, C., Mani, K. A., Weldon, C. B., Trosman, J. R., Rapkin, B., Jinnett, K., Fleurimont, J., Kaur, S., & Jariwala, S. P.


This study examined community reactions to a self-management toolkit for patients with upper respiratory symptoms to inform mobile e-health app development, based on the "4R" (Right Information, Right Care, Right Patient, Right Time) care planning and management model. The research involved distributing the 4R Cold, Flu and COVID-19 Information Tool along with evaluation surveys through multiple channels to assess community perceptions of the toolkit’s accessibility, preferences for sharing symptoms with clinicians, social media use and e-health literacy among 106 Bronx residents.

Ch’en, P. Y., Day, W., Arora, S., Lutz, C. L., Nazar, N., & Jariwala, S. P.

This cross-sectional observational study examined the attitudes and training needs regarding healthcare technology principles among medical trainees at different educational stages and disciplines. The research assessed current interest in healthcare technology training among MD students, MD/PhD students, residents, fellows, graduate/PhD students and postdocs through survey methodology, analyzing associations between trainee type, gender and survey timing with metrics of interest in digital health education.

McCarthy, D., Lutz, C., Teigman, A., Irizarry, E., & Friedman, B.

A randomized, factorial, dose-finding study of sphenopalatine ganglion block with bupivacaine for the treatment of emergency department patients with headaches.

Lutz, C., Esses, D., Llamzon, J., Mainolfi, M., Baghizadeh-Toosi, B., Sperling, J., Tarr, M., Dhillon, S., Sanapala, S., & Jones, M.

Saggar, V., O’Donnell, P., Moss, H., Yoon, A., Lutz, C., Restivo, A., Ahmed, O., Guha, D., Jafri, F., & Singh, M.

This prospective, observational study evaluated the efficacy of virtual reality (VR) hemorrhage training compared to traditional in-person instruction for tourniquet application skills among 53 emergency medicine residents at a Level I trauma center. Participants were randomly assigned to either control or VR training groups and assessed using the National Registry Hemorrhage Control Skills Lab rubric immediately after training and at 3-month retention testing, measuring successful tourniquet placement and time to completion.

Moss, H., Gutierrez, B., Rashed, A., Thomas, J., Trump, N., Manzur, M., Lutz, C., Turrin, D., Lehman, V., & Cassara, M.

Woman with long dark hair reviews academic research on a laptop in a quiet study space with blue lighting.

Research Training Programs

Since 2022, Emergency Medicine residents have had the opportunity to participate in structured research and innovation tracks. These longitudinal programs provide tailored mentorship in clinical research methods, study design, grant writing, biostatistics, quality improvement and digital health development. Residents in these tracks gain hands-on experience designing and implementing research studies, presenting at national conferences and contributing to peer-reviewed publications—helping them build the skills and networks to become future leaders in academic emergency medicine and healthcare innovation.

Through a mix of National Institutes of Health (NIH)-funded research, national collaborations through the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) and foundation- and Department-supported studies, our Division continues to generate evidence that improves emergency care in the Bronx and informs best practices around the world.

Monthly research meetings offer a collaborative forum for students, residents, fellows and faculty to refine their ideas into actionable protocols. With the support of Montefiore Einstein’s Clinical and Translational Science Award (CTSA) infrastructure and a wealth of local expertise, we provide the resources and mentorship needed to transform questions at the bedside into discoveries with lasting impact.

The Latest Research

Stay up to date on the latest cancer research news and advances at the Montefiore Einstein Department of Emergency Medicine.

Your Generosity Makes a Difference

Your contribution to Montefiore Einstein Emergency Medicine supports our vital efforts in research, education and clinical excellence.