Falcone Laboratory for Integrative Neuroscience Research

The Falcone Laboratory is interested in identifying the neural mechanisms of social behavior, such as those that allow us to infer what others are thinking and feeling, and to distinguish between the self and others. These social skills are impaired in individuals with autism spectrum disorder (ASD). We examine this topic in non-human primates at the level of single neurons and local field potentials, and we study how the prefrontal cortex (PFC) contributes to social behavior.

Motivation is a complex behavioral phenomenon that balances the attractiveness of achieving a goal or reward with the effort required to obtain it. Difficulty in maintaining adaptive motivational states is a common feature of many neuropsychiatric disorders, including depression, obsessive-compulsive disorder, and substance use disorders, as well as degenerative neurological conditions, such as Parkinson's disease and frontotemporal dementia.

Our laboratory primarily uses classical extracellular neural recordings to describe how neurons encode reward value and confidence level when making value-based decisions.

Acetylcholine plays a central role in the regulation of many cognitive behaviors, including learning and motivation. What are the underlying mechanisms? And once identified, how do these mechanisms relate to the abnormal behavior?

We use state-of-the-art techniques, such as chemogenetics (DREADDs) for transient inactivation of specific brain regions, as well as silencing of targeted gene expression by RNA interference, to establish the causal role of cholinergic signaling in such behaviors and to describe the underlying mechanisms.

Wang S*, Falcone R*, Richmond B and Averbeck B. Attractor dynamics reflect decision confidence in macaque prefrontal cortex. Nature Neuroscience. 2023.  *Equal Contribution

Falcone R, Cirillo R, Ceccarelli F, and Aldo Genovesio. Neural Representation of Others during Action Observation in Posterior Medial Prefrontal Cortex. Cerebral Cortex. 2022

Lerchner W., Adil AA, Mumuney S, Wang W, Falcone R, Turchi J, and Richmond BJ.  (2021) RNAi and chemogenetic reporter coregulation in primate striatal interneurons. Gene Therapy. 2021.

Falcone R, Weintraub DB, Setogawa T, Wittig JH, Chen G, and Richmond BJ. Temporal coding of reward value in monkey ventral striatal Tonically Active Neurons. Journal of Neuroscience. 2019.

Falcone R, Cirillo R, Ferraina S, and Genovesio A. Neural activity in macaque medial frontal cortex represents others’ choices. Scientific Reports. 2017.  

Falcone R, Brumanonti E, Ferraina S, and Genovesio A. (2016) Neural encoding of self and another agent’s goal in the primate prefrontal cortex: Human-Monkey interactions. Cerebral Cortex. 2016.