John M. Greally

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John M. Greally, MD

Genetics Epigenetics

Director, Center for Epigenomics
Attending physician
Professor and Chief Division of Genomics Department of Genetics
Professor, Department of Genetics
Professor, Department of Pediatrics (Pediatric Genetic Medicine)
Chief, Division of Genomics Department of Genetics
Director, Center for Epigenomics
Faculty Scholar for Epigenomics
Faculty Advisor, Computational Genomics Core Department of Genetics
Faculty Advisor, Epigenetics Shared Facility Department of Genetics

Areas of Expertise

Computational biology
DNA methylation

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Expert Summary

Dr. Greally began his career as a pediatrician who subspecialized in clinical genetics, seeing patients with genetic syndromes, birth defects and developmental problems. Now, Dr. Greally seeks to understand how genetic disease is caused not by DNA mutations, but due to abnormalities in how genes are switched off and on – a field known as epigenomics.

Dr. Greally’s research focuses on epigenetic abnormalities in human diseases such as breast cancer, type 2 diabetes, viral hepatitis, and allergies and on epigenetic regulation of stem cell differentiation. He also serves on the editorial board of the journal Epigenetics & Chromatin.