Tratamiento del cáncer nasofarÃngeo
If your child is diagnosed with nasopharyngeal cancer, a type of cancer that develops inside the nose or upper part of the throat, you want them to be in the best possible medical hands. They will be at the Montefiore Einstein Comprehensive Cancer Center at the Children’s Hospital at Montefiore Einstein (CHAM). Our pediatric oncology (cancer) programs at CHAM are ranked in the top 1% of all hospitals in the nation for cancer care according to U.S. News & World Report, providing exceptional care for children from the New York metropolitan area, across the nation and around the world.
In a supportive, nurturing environment, we offer a full range of treatments, including surgery, chemotherapy, radiation therapy and immunotherapy. Our research efforts are designed to test promising new therapies and clinical trials offer the most advanced, up-to-date treatments options.
Con médicos, enfermeras, especialistas y personal de apoyo excepcionales, nuestro enfoque multidisciplinario y colaborativo para el tratamiento garantiza que su hijo recibirá la mejor atención en un entorno de apoyo y protección.
When you want only the best for your child, turn to the caring specialists at Montefiore Einstein Comprehensive Cancer Center at CHAM who are passionate about ending cancer and addressing your child’s whole health needs.
Como centro del cáncer designado por el Instituto Nacional del Cáncer (NCI, por sus siglas en inglés) Montefiore Einstein Comprehensive Cancer Center apoya la misión y las normas del NCI. La siguiente información sobre los tipos de cáncer, prevención y tratamientos ha sido facilitada por el NCI.
Childhood Nasopharyngeal Cancer (PDQ®)–Patient Version
What is childhood nasopharyngeal cancer?
Childhood nasopharyngeal cancer is a rare type of cancer that forms in the tissue lining the nasopharynx. The nasopharynx is the upper part of the throat behind the nose. The nostrils allow air into the nasopharynx. Air and food pass through the pharynx on the way to the trachea or esophagus.
Nasopharyngeal cancer is more common in children aged 10 to 19 years than in children younger than 10 years.
Anatomy of the nasopharynx. The nasopharynx is in the upper part of the pharynx (throat) behind the nose. The nostrils lead into the nasopharynx. An opening on each side of the nasopharynx leads into the ear.
Causes and risk factors for childhood nasopharyngeal cancer
Childhood nasopharyngeal cancer is caused by certain changes in the way the cells in the nasal cavity and top part of the throat function, especially how they grow and divide into new cells. Often, the exact cause of these changes is unknown. Learn more about how cancer develops at What Is Cancer?
A risk factor is anything that increases the chance of getting a disease. A known risk factor for childhood nasopharyngeal cancer is infection from the Epstein-Barr virus (EBV). Not every child with this risk factor will develop nasopharyngeal cancer. And it will develop in some children who don’t have a known risk factor. Talk with your child's doctor if you think your child may be at risk.
Symptoms of childhood nasopharyngeal cancer
Children may not have symptoms of nasopharyngeal cancer until the tumor has grown bigger. It’s important to check with your child's doctor if your child has:
- a headache
- a blocked or stuffy nose
- nosebleeds
- an earache
- an ear infection
- pérdida auditiva
- problems moving the jaw
- trouble speaking
- trouble seeing or a droopy eyelid
- lumps in the neck that may be painful
These symptoms may be caused by problems other than nasopharyngeal cancer. The only way to know is for your child to see a doctor.
Tests to diagnose childhood nasopharyngeal cancer
If your child has symptoms that suggest nasopharyngeal cancer, the doctor will need to find out if these are due to cancer or another problem. The doctor will ask when the symptoms started and how often your child has been having them. They will also ask about your child’s personal and family medical history and do a physical exam. Depending on these results, the doctor may recommend other tests. If your child is diagnosed with nasopharyngeal cancer, the results of these tests will help plan treatment.
Diagnostic tests
The tests used to diagnose nasopharyngeal cancer may include:
Imágenes por resonancia magnética (IRM)
MRI uses a magnet, radio waves, and a computer to make a series of detailed pictures of areas of the body, such as the head and neck. This procedure is also called nuclear magnetic resonance imaging (NMRI).
Nasal endoscopy
Nasal endoscopy is a procedure to look at organs and tissues inside the body to check for abnormal areas. A flexible or rigid endoscope is inserted through the nose. An endoscope is a thin, tube-like instrument with a light and a lens for viewing. It may also have a tool to remove tissue samples, which are checked under a microscope by a pathologist for signs of disease.
Epstein-Barr virus (EBV) tests
Epstein-Barr virus (EBV) tests use a sample of blood to check for antibodies to the Epstein-Barr virus and DNA markers of the Epstein-Barr virus. These are found in the blood of patients who have been infected with EBV.
Tests to stage nasopharyngeal cancer
If your child is diagnosed with nasopharyngeal cancer, they will be referred to a pediatric oncologist. This is a doctor who specializes in staging and treating nasopharyngeal cancer and other cancers. They will recommend tests to determine the extent (stage) of cancer. Sometimes the cancer is only in the nasopharynx. Or, it may have spread to other parts of the body. The process of learning the extent of cancer in the body is called staging. It is important to know the stage of the nasopharyngeal cancer in order to plan the best treatment.
Most children with nasopharyngeal cancer are at an advanced stage at the time of diagnosis. Nasopharyngeal cancer spreads most often to the bone, lung, and liver.
For information about a specific stage of nasopharyngeal cancer, see Childhood Nasopharyngeal Cancer Stages.
The following procedures may be used to determine the nasopharyngeal cancer stage:
examen neurológico
A neurologic exam is a series of questions and tests done to check the brain, spinal cord, and nerve function. The exam checks a person’s mental status, coordination, and ability to walk normally, and how well the muscles, senses, and reflexes work. This may also be called a neuro exam.
RadiografÃa de tórax
Chest x-ray is a type of radiation that can go through the body and make pictures of the organs and bones inside the chest.
Exploración PET-TC
PET-CT scan combines the pictures from a positron emission tomography (PET) scan and a computed tomography (CT) scan. The PET and CT scans are done at the same time on the same machine. The combined scans make more detailed pictures than either test would make by itself.
- For the PET scan, a small amount of radioactive sugar (also called radioactive glucose) is injected into a vein. The PET scanner rotates around the body and makes a picture of where sugar is being used in the body. Cancer cells show up brighter in the picture because they are more active and take up more sugar than normal cells do.
- For the CT scan (CAT scan), a computer linked to an x-ray machine makes a series of detailed pictures of areas inside the body. The pictures are taken from different angles and are used to create 3-D views of tissues and organs. A dye may be injected into a vein or swallowed to help the organs or tissues show up more clearly. Often, a chest CT scan is done. This procedure is also called computed tomography, computerized tomography, or computerized axial tomography. Learn more about Computed Tomography (CT) Scans and Cancer.
Getting a second opinion
You may want to get a second opinion to confirm your child’s cancer diagnosis and treatment plan. If you seek a second opinion, you will need to get medical test results and reports from the first doctor to share with the second doctor. The second doctor will review the pathology report, slides, and scans. This doctor may agree with the first doctor, suggest changes to the treatment plan, or provide more information about your child’s cancer.
To learn more about choosing a doctor and getting a second opinion, visit Finding Cancer Care. You can contact NCI's Cancer Information Service via chat, email, or phone (both in English and Spanish) for help finding a doctor or hospital that can provide a second opinion. For questions you might want to ask at your child's appointments, visit Questions to Ask Your Doctor about Cancer.
Stages of childhood nasopharyngeal cancer
The cancer stage describes the extent of cancer in the body, such as the size of the tumor, whether it has spread, and how far it has spread from where it first formed. It is important to know the stage of nasopharyngeal cancer to plan the best treatment.
There are several staging systems for cancer. Nasopharyngeal cancer staging usually uses the TNM staging system. You may see your child’s cancer described by this staging system in the pathology report. Based on the TNM results, a stage (I, II, III, or IV, also written as 1, 2, 3, or 4) is assigned to your child’s cancer. When talking with you about your child’s cancer, your child’s doctor may describe it as one of these stages.
Más información sobre la estadificación del cáncer .
Learn about the tests and procedures used to determine the stage of nasopharyngeal cancer.
Stage 0 nasopharyngeal cancer
In stage 0, abnormal cells are found in the lining of the nasopharynx. These abnormal cells may become cancer and spread into nearby normal tissue. Stage 0 is also called carcinoma in situ.
Stage I nasopharyngeal cancer
In stage I, nasopharyngeal cancer has formed and is found in the nasopharynx only or has spread from the nasopharynx to the oropharynx and/or nasal cavity.
El tamaño de un tumor suele medirse en centÃmetros (cm) o pulgadas. Algunos alimentos comunes que pueden usarse para mostrar el tamaño de un tumor en cm incluyen: un guisante (1 cm), un cacahuete (2 cm), una uva (3 cm), una nuez (4 cm), una lima (5 cm o 2 pulgadas), un huevo (6 cm), un melocotón (7 cm) y una toronja (10 cm o 4 pulgadas).
Stage II nasopharyngeal cancer
Stage II is based on the location of the cancer and whether it has spread. A child may have one of the following:
- Cancer has spread to one or more ganglios linfáticos on one side of the neck and/or to one or more lymph nodes on one or both sides of the back of the throat. The affected lymph nodes are 6 centimeters or smaller. Cancer is found:
- in the nasopharynx only or has spread from the nasopharynx to the oropharynx and/or to the nasal cavity; or
- only in the lymph nodes in the neck. The cancer cells in the lymph nodes are infected with Epstein-Barr virus (a virus linked to nasopharyngeal cancer). Cancer was not found in the nasopharynx.
- Cancer has spread to the parapharyngeal space and/or nearby muscles. Cancer may have also spread to one or more lymph nodes on one side of the neck and/or to one or more lymph nodes on one or both sides of the back of the throat. The affected lymph nodes are 6 centimeters or smaller.
Stage III nasopharyngeal cancer
Stage III is based on the location of the cancer and whether it has spread. A child may have one of the following:
- Cancer has spread to one or more lymph nodes on both sides of the neck. The affected lymph nodes are 6 centimeters or smaller. Cancer is found:
- in the nasopharynx only or has spread from the nasopharynx to the oropharynx and/or to the nasal cavity; or
- only in the lymph nodes in the neck. The cancer cells in the lymph nodes are infected with Epstein-Barr virus (a virus linked to nasopharyngeal cancer). Cancer was not found in the nasopharynx.
- Cancer has spread to the parapharyngeal space and/or nearby muscles. Cancer has also spread to one or more lymph nodes on both sides of the neck. The affected lymph nodes are 6 centimeters or smaller.
- Cancer has spread to the bones at the bottom of the skull, the bones in the neck, jaw muscles, and/or the sinuses around the nose and eyes. Cancer may have also spread to one or more lymph nodes on one or both sides of the neck and/or the back of the throat. The affected lymph nodes are 6 centimeters or smaller.
Stage IV nasopharyngeal cancer
Stage IV is subdivided based on whether the cancer has spread to other tissue.
- In stage IVA:
- Cancer has spread to the brain, the cranial nerves, the hypopharynx, the salivary gland in front of the ear, the bone around the eye, and/or the soft tissues of the jaw. Cancer may have also spread to one or more lymph nodes on one or both sides of the neck and/or the back of the throat. The affected lymph nodes are 6 centimeters or smaller; or
- Cancer has spread to one or more lymph nodes on one or both sides of the neck. The affected lymph nodes are larger than 6 centimeters and/or are found in the lowest part of the neck.
- In stage IVB: Cancer has spread beyond the lymph nodes in the neck to distant lymph nodes, such as those between the lungs, below the collarbone, or in the armpit or groin, or to other parts of the body, such as the lung, bone, or liver.
Stage IV nasopharyngeal cancer is also called metastatic nasopharyngeal cancer. Metastatic cancer happens when cancer cells travel through the lymphatic system or blood and form tumors in other parts of the body. The metastatic tumor is the same type of cancer as the primary tumor. For example, if nasopharyngeal cancer spreads to the lung, the cancer cells in the lung are actually nasopharyngeal cancer cells. The disease is called metastatic nasopharyngeal cancer, not lung cancer. Learn more in Metastatic Cancer: When Cancer Spreads.
Recurrent nasopharyngeal cancer
Recurrent nasopharyngeal cancer is cancer that has come back after it has been treated. Nasopharyngeal cancer may come back in the nasopharynx, or in other parts of the body, such as the bone, lung, or liver. Tests will be done to help determine where the cancer has returned in the body, if it has spread, and how far. The type of treatment that your child will have for recurrent nasopharyngeal cancer will depend on where it has come back.
Learn more in Recurrent Cancer: When Cancer Comes Back.
Types of treatment for childhood nasopharyngeal cancer
Who treats children with nasopharyngeal cancer?
A pediatric oncologist, a doctor who specializes in treating children with cancer, oversees treatment of nasopharyngeal cancer. The pediatric oncologist works with other health care providers who are experts in treating children with cancer and who specialize in certain areas of medicine. Other specialists may include:
Treatment options
There are different types of treatment for children and adolescents with nasopharyngeal cancer. You and your child’s care team will work together to decide treatment. Many factors will be considered, such as your child’s overall health and whether the cancer is newly diagnosed or has come back.
Your child’s treatment plan will include information about the cancer, the goals of treatment, treatment options, and the possible side effects. It will be helpful to talk with your child’s care team before treatment begins about what to expect. For help every step of the way, visit our booklet, Children with Cancer: A Guide for Parents.
The types of treatment your child might have include:
La quimioterapia
Chemotherapy (also called chemo) uses drugs to stop the growth of cancer cells. Chemotherapy either kills the cancer cells or stops them from dividing. Chemotherapy may be given alone or with other types of treatment, such as radiation therapy.
Chemotherapy for nasopharyngeal cancer is injected into a vein. When given this way, the drugs enter the bloodstream to reach cancer cells throughout the body. Chemotherapy used alone or in combination to treat nasopharyngeal cancer in children include:
Other chemotherapy not listed here may also be used.
Más información sobre cómo funciona la quimioterapia, cómo se administra, los efectos secundarios comunes y más en Quimioterapia para tratar el cáncer .
La radioterapia
Radiation therapy uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. Nasopharyngeal cancer is treated with external beam radiation therapy. This type of radiation therapy uses a machine outside the body to send radiation toward the area of the body with cancer. Radiation therapy may be given alone or with other treatments, such as chemotherapy.
Más información sobre la radioterapia de haz externo para el cáncer y los efectos secundarios de la radioterapia.
CirugÃa
Surgery to remove the tumor is done if the tumor has not spread throughout the nasal cavity and throat at the time of diagnosis.
Inmunoterapia
Immunotherapy uses a person's immune system to fight cancer. Interferon may be used to treat nasopharyngeal cancer.
Más información sobre la inmunoterapia para tratar el cáncer.
Ensayos clÃnicos
Para algunos niños, participar en un ensayo clÃnico puede ser una opción. Existen distintos tipos de ensayos clÃnicos para el cáncer infantil. Por ejemplo, un ensayo de tratamiento prueba nuevos tratamientos o nuevas formas de utilizar los tratamientos actuales. Los ensayos de cuidados paliativos y de apoyo buscan formas de mejorar la calidad de vida, especialmente para aquellos que tienen efectos secundarios a causa del cáncer y su tratamiento.
Puede usar la búsqueda de ensayos clÃnicos para encontrar ensayos clÃnicos sobre cáncer financiados por el NCI que aceptan participantes. Esta búsqueda le permite filtrar los ensayos según el tipo de cáncer, la edad de su hijo/a y el lugar donde se realizan. Puede encontrar ensayos clÃnicos financiados por otras organizaciones en el sitio web ClinicalTrials.gov .
Más información sobre ensayos clÃnicos, incluido cómo encontrar y participar en uno de ellos, en Información sobre ensayos clÃnicos para pacientes y cuidadores.
Treatment of childhood nasopharyngeal cancer
Treatment of newly diagnosed nasopharyngeal cancer in children may include:
- Chemotherapy followed by chemotherapy and radiation therapy given at the same time. Interferon may also be given.
- Surgery to remove the tumor.
Treatment of refractory or recurrent nasopharyngeal cancer is chemotherapy.
Puede utilizar la búsqueda de ensayos clÃnicos y encontrar ensayos clÃnicos sobre cáncer patrocinados por el NCI que acepten participantes. La búsqueda le permite filtrar los ensayos según el tipo de cáncer, su edad y el lugar donde se realizan los ensayos. También encontrará información general sobre los ensayos clÃnicos.
Prognostic factors for childhood nasopharyngeal cancer
If your child has been diagnosed with nasopharyngeal cancer, you likely have questions about how serious the cancer is and your child’s chances of survival. The likely outcome or course of a disease is called prognosis. The prognosis can be affected by whether the cancer has spread to other parts of the body at the time of diagnosis and whether the cancer has just been diagnosed or has recurred (come back). No two people are alike, and responses to treatment can vary greatly. Your child’s cancer care team is in the best position to talk with you about your child’s prognosis.
Side effects and late effects of treatment
Cancer treatments can cause side effects. Which side effects your child might have depends on the type of treatment they receive, the dose, and how their body reacts. Talk with your child's treatment team about which side effects to look for and ways to manage them.
Para obtener más información sobre los efectos secundarios que aparecen durante el tratamiento del cáncer, consulte la sección Efectos secundarios.
Los problemas derivados del tratamiento del cáncer que comienzan 6 meses o más después del tratamiento y continúan durante meses o años se denominan efectos tardÃos. Los efectos tardÃos del tratamiento del cáncer pueden incluir:
- problems with the thyroid gland
- decreased mouth function
- hearing loss or chronic ear infections
- dental cavities
- chronic sinusitis
- cambios en el estado de ánimo, los sentimientos, el pensamiento, el aprendizaje o la memoria
- second cancers (new types of cancer) or other problems
Some late effects may be treated or controlled. It is important to talk with your child's doctors about the possible late effects caused by some treatments. Learn more about Late Effects of Treatment for Childhood Cancer.
Follow-up care
A medida que su hijo se somete al tratamiento, se le harán pruebas o controles de seguimiento. Es posible que se repitan algunas pruebas que se realizaron para diagnosticar o estadificar el cáncer para ver qué tan bien está funcionando el tratamiento. Las decisiones sobre si continuar, cambiar o suspender el tratamiento pueden basarse en los resultados de estas pruebas.
Algunas de las pruebas se seguirán realizando periódicamente después de que finalice el tratamiento. Los resultados de estas pruebas pueden mostrar si la afección de su hijo ha cambiado o si el cáncer ha reaparecido (recaÃdo).
Coping with your child's cancer
When your child has cancer, every member of the family needs support. Taking care of yourself during this difficult time is important. Reach out to your child’s treatment team and to people in your family and community for support. To learn more, visit Support for Families: Childhood Cancer and the booklet Children with Cancer: A Guide for Parents.
Recursos relacionados
Para obtener más información sobre el cáncer infantil y otros recursos generales sobre el cáncer, consulte:
Información sobre este resumen del PDQ
Acerca del PDQ
Physician Data Query (PDQ) es la base de datos integral sobre el cáncer del Instituto Nacional del Cáncer (NCI). La base de datos del PDQ contiene resúmenes de la última información publicada sobre prevención, detección, genética, tratamiento, atención médica de apoyo y medicina complementaria y alternativa relacionada con el cáncer. La mayorÃa de los resúmenes se redactan en dos versiones. Las versiones para profesionales de la salud contienen información detallada escrita en lenguaje técnico. Las versiones para pacientes están redactadas en un lenguaje fácil de entender, que no es técnico. Ambas versiones contienen información sobre el cáncer correcta y actualizada. La mayorÃa de las versiones también están disponibles en español.
PDQ is a service of the NCI. The NCI is part of the National Institutes of Health (NIH). NIH is the federal government’s center of biomedical research. The PDQ summaries are based on an independent review of the medical literature. They are not policy statements of the NCI or the NIH.
Propósito de este resumen
This PDQ cancer information summary has current information about the treatment of childhood nasopharyngeal cancer. It is meant to inform and help patients, families, and caregivers. It does not give formal guidelines or recommendations for making decisions about health care.
Revisores y actualizaciones
Los consejos editoriales escriben los resúmenes de información sobre el cáncer del PDQ y los mantienen actualizados. Estos consejos están conformados por equipos de especialistas en el tratamiento del cáncer y otras especialidades relacionadas con esta enfermedad. Los resúmenes se revisan periódicamente y se modifican cuando hay información nueva. La fecha de actualización al pie de cada resumen indica cuándo fue el cambio más reciente.
La información de este resumen para pacientes procede de la versión para profesionales de la salud, la cual el Consejo editorial del PDQ sobre el tratamiento pediátrico revisa y actualiza de forma periódica según sea necesario.
Información sobre ensayos clÃnicos
Un ensayo clÃnico es un estudio para responder a una pregunta cientÃfica; por ejemplo, si un tratamiento es mejor que otro. Los ensayos se basan en estudios anteriores y en lo que se ha aprendido en el laboratorio. Cada ensayo responde a ciertas preguntas cientÃficas para descubrir mejores maneras de ayudar a los pacientes con cáncer. Durante los ensayos clÃnicos de tratamiento, se recopila información sobre los efectos de un tratamiento nuevo y su eficacia. Si un ensayo clÃnico demuestra que un tratamiento nuevo es mejor que uno que se utiliza actualmente, el tratamiento nuevo puede convertirse en “estándarâ€. Participar en un ensayo clÃnico puede ser una opción para los pacientes. Algunos ensayos clÃnicos están abiertos solo a pacientes que aún no han comenzado el tratamiento.
Los ensayos clÃnicos se pueden encontrar en lÃnea en el sitio web del NCI. Para obtener más información, llame al Servicio de Información sobre el Cáncer (CIS, por sus siglas en inglés), el centro de contacto del NCI, al 1-800-4-CANCER (1-800-422-6237).
Permiso de uso de este resumen
PDQ is a registered trademark. The content of PDQ documents can be used freely as text. It cannot be identified as an NCI PDQ cancer information summary unless the whole summary is shown and it is updated regularly. However, a user would be allowed to write a sentence such as “NCI’s PDQ cancer information summary about breast cancer prevention states the risks in the following way: [include excerpt from the summary].”
La forma recomendada para citar este resumen del PDQ es:
PDQ® Pediatric Treatment Editorial Board. PDQ Childhood Nasopharyngeal Cancer. Bethesda, MD: National Cancer Institute. Updated <MM/DD/YYYY>. Available at: https://www.cancer.gov/types/head-and-neck/patient/child/nasopharyngeal-treatment-pdq. Accessed <MM/DD/YYYY>.
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Descargo de responsabilidad
La información de estos resúmenes no debe utilizarse para tomar decisiones sobre reembolsos de seguros. Puede encontrar más información sobre la cobertura de seguros disponible en Cancer.gov/espanol en la página Manejo de la atención médica del cáncer.
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Updated:
Source URL: https://www.cancer.gov/node/1103246/syndication
Agencia de origen: National Cancer Institute (NCI)
Captured Date: 2018-01-09 00:10:29.0