Metastasis causes a majority of cancer deaths, yet the mechanisms that fuel each step of the metastatic process are poorly understood. In a study published online on November 16 in Nature Reviews Cancer, David Entenberg, Ph.D., Maja Oktay, M.D., Ph.D., and John Condeelis, Ph.D., provide an overview of recent research using multiphoton intravital imaging to study cancer progression and metastasis. Multiphoton intravital imaging has enabled scientists to discover biomarkers and therapies that have influenced clinical care. The authors note that the imaging technique can be used to investigate the tumor microenvironment and therapeutic response to evaluate the effectiveness of newly developed anti-cancer agents.

Dr. Entenberg is an associate professor of pathology and co-director of the Gruss Lipper Biophotonics Center at Einstein. Dr. Oktay is professor of pathology, co-leader of Tumor Microenvironment and Metastasis Program at Montefiore Einstein Cancer Center, and director of the New York Pathology Oncology Group. Dr. Condeelis is the Judith & Burton P. Resnick Chair in Translational Research, and director of the Integrated Imaging Program for Cancer Research at Einstein.

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